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US 2025/0375392 A1Published application
Branched Tail Lipids and Uses Thereof
OwnerKathryn Whitehead, Mariah Lynn Arralinventors
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Abstract
Ionizable lipids having branched tails, nanoparticles containing the ionizable lipids, compositions containing the nanoparticles, and methods for using the ionizable lipids, nanoparticles, and compositions to deliver agents (e.g., RNAs) to cells, tissues, and/or organs are provided herein.
Claims20
A lipid-containing particle comprising:
- a lipidoid;
- cholesterol or a derivative thereof;
- a helper lipid;
- and
- a polyethylene glycol (PEG)-based compound,
- wherein said lipidoid comprises an amine-containing head and one or more acrylate tails, wherein each of said one or more acrylate tails comprises an alkyl chain of 10 or 11 carbon atoms, and wherein said alkyl chain of each of said one or more acrylate tails comprises a one, two, three, four, or five carbon atom branch.
3 more elements
A lipid-containing particle comprising:
- a lipidoid;
- cholesterol or a derivative thereof;
- a helper lipid;
- and
- a polyethylene glycol (PEG)-based compound,
- wherein said lipidoid comprises an amine-containing head and one or more acrylate tails, wherein said amine-containing head is N1-(3-aminopropyl)-N1-methylpropane-1,3-diamine, and wherein said one or more acrylate tails comprise one or more of a decan-3-yl acrylate tail, a decan-5-yl acrylate tail, a 2-methylnonyl acrylate tail, a 2-ethyloctyl acrylate tail, a 2-propylheptyl acrylate tail, a 3-ethyloctyl acrylate tail, a 4-ethyloctyl acrylate tail, a 4-propylheptyl acrylate tail, a 5-methynonyl acrylate tail, a 6-ethyloctyl acrylate tail, an undecan-3-yl acrylate tail, an undecan-4-yl acrylate tail, an undecan-5-yl acrylate tail, an undecan-6-yl acrylate tail, a 7-ethylnonyl acrylate tail, an 8-methyldecyl acrylate tail, and a 9-methyldecyl acrylate tail.
3 more elements
Dependencies are inferred from the claim text.