Oral appliance for delivering medicaments

An oral appliance for delivering a medication to teeth and gums of a subject comprising a generally U-shaped tray having an exterior surface, an interior surface, an upper end, a lower end, a front end, a back end, a right side, and a left side, wherein the tray comprises:

• a receptacle on the interior surface of the tray for receiving teeth of the subject, the receptacle having a proximal surface, a front end, a back end, a right side, a left side, a lingual side and a buccal side;
• a right side buccal wall connected to the right side of the receptacle, the right side buccal wall extending apically from a proximal end to a distal end from the buccal side of the receptacle, wherein the distal end of the right side buccal wall is adapted to extend over the gums of the subject and beyond a bony height of contour of teeth adjacent to the right side buccal wall when the appliance is worn by the subject;
• a right side lingual wall connected to the right side of the receptacle, the right side lingual wall extending apically from a proximal end to a distal end from the lingual side of the receptacle, wherein the distal end of the right side lingual wall is adapted to extend over the gums of the subject and beyond a bony height of contour of teeth adjacent to the right side lingual wall when the appliance is worn by the subject, wherein the right side buccal wall and right side lingual wall are connected by a right side posterior wall at the back end of the tray having a distal end;
• a left side buccal wall connected to the left side of the receptacle, the left side buccal wall extending apically from a proximal end to a distal end from the buccal side of the receptacle, wherein the distal end of the left side buccal wall is adapted to extend over the gums of the subject and beyond a bony height of contour of teeth adjacent to the left side buccal wall when the appliance is worn by the subject;
• a left side lingual wall connected to the left side of the receptacle, the left side lingual wall extending apically from a proximal end to a distal end from the lingual side of the receptacle, wherein the distal end of the left side lingual wall is adapted to extend over the gums of the subject and beyond a bony height of contour of teeth adjacent to the left side lingual wall when the appliance is worn by the subject, wherein the left side buccal wall and the left side lingual wall are connected by a left side posterior wall at the back end of the tray having a distal end;
• a seal formed at the distal end of the receptacle, the seal extending around the right side buccal wall, the right side lingual wall, the right side posterior wall, the left side buccal wall, the left side lingual wall, and the left side posterior wall;
• and
• one or more chambers in at least one of the right side buccal wall, the right side lingual wall, the left side buccal wall, or the left side lingual wall between the seal and the proximal surface of the receptacle, each of the chambers comprising an interior surface and an interior volume for retaining the medication, the chambers being positioned adjacent to embrasure spaces of the subject's teeth when the appliance is worn by the subject.