Method for improving the real-world skin sensitization impact of formulated products

A system to predictively assess skin sensitization of a personal care product formulation including a plurality of ingredients, the system comprising:

• a computing device;
• a memory storing instructions that, when executed by the computing device, cause the computing device to perform operations comprising:
• calculating an upper confidence limit at a desired confidence level from multiple tests for skin sensitization of each of the ingredients in the personal care product formulation in order to define calculated skin sensitization values for respective ingredients;
• applying at least one safety factor to the calculated skin sensitization values for the ingredients to define adjusted skin sensitization values for the respective ingredients;
• summing the adjusted skin sensitization values of the ingredients to define a total sensitization of the personal care product formulation;
• and
• comparing the total sensitization to a target product sensitization for the personal care product formulation, wherein the product formulation does not require further testing and is capable of application to skin by users when the total sensitization is less than the target product sensitization.

A method of preparing a personal care product comprising:

• selecting a plurality ingredients for use in a personal care product formulation;
• calculating an upper confidence limit at a desired confidence level from multiple physical tests for skin sensitization of each of the ingredients in the personal care product formulation in order to define calculated skin sensitization values for the respective ingredients;
• applying at least one safety factor to at least one of the calculated skin sensitization values for the ingredients to define adjusted skin sensitization values for the respective ingredients;
• summing the adjusted skin sensitization values of the ingredients to define a total sensitization of the personal care product formulation;
• comparing the total sensitization to a target product sensitization for the personal care product formulation;
• and
• if the total sensitization is less that the target product sensitization, combining the ingredients to form the personal care product, wherein the product formulation for the personal care product formulation does not require further testing and is capable of application to skin by users.