System and method for non-invasively controlling autonomic nerve activity

A system for controlling nerve activity in a subject, the system comprising:

• a plurality of electrodes configured for placement at locations proximate to nerves of the subject;
• a signal generator configured to generate electrical stimulation;
• and
• a digital logic device configured to:
• identify a condition based on sympathetic nerve activity, blood pressure, or cardiac signals;
• and
• in response to the identification of the condition, direct the signal generator to deliver, using the plurality of electrodes, an electrical stimulation configured to control a sympathetic nerve activity by remodeling at least one neural structure in the subject, the electrical stimulation delivered to the at least one neural structure via the nerves innervating skin of the subject.

A system for monitoring sympathetic nerve activity in a subject, the system comprising:

• a plurality of electrodes configured for placement at locations proximate to nerves;
• a signal detector configured to sample electrical signals detected by the plurality of electrodes;
• and
• at least one processor configured to:
• receive signal data corresponding to the electrical signals sampled by the signal detector;
• apply a filter to the received signal data to generate filtered signal data;
• estimate a sympathetic nerve activity based on the filtered signal data;
• and
• generate a report indicative of the estimated sympathetic nerve activity, the report containing information for guiding treatment of a condition, the treatment including:
• treatment of the condition via remodeling a neural structure, treatment of hypertension via renal denervation, treatment of heart failure via renal denervation, treatment of hypertension, treatment of heart failure, treatment for hyperhidrosis, treatment for paralysis, treatment for stroke, treatment for diabetes, treatment for seizures, treatment for syncope, treatment for disturbance of consciousness, treatment for hyperthyroidism, or treatment for neuromuscular disease.