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AssigneeShenzhen Baishitong Technology Development Company Limited
InventorsJing LOU, Jianhe CHEN, Dongmei SU, Zheng JIN, Yunying LV, Ruolan ZHANG, Ruochen PEI, Yanmei OU, Xiao QU, Xie XIE, Jing ZHANG, Lin ZENG
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The present disclosure provides a bifunctional molecule formed by connecting an Fc-mutated antibody to a cytokine, and use of the bifunctional molecule in the preparation of a therapeutic antibody drug. These Fc-mutated monoclonal antibodies or monoclonal antibody/antigen complexes or Fc fusion proteins can significantly reduce in vivo toxic side effects while maintaining their pre-mutation in vivo and in vitro biological activity.
A bifunctional molecule, comprising an Fc-mutated antibody and cytokine, wherein the Fc-mutated antibody and the cytokine are connected.
Dependencies are inferred from the claim text.