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AssigneeOkinawa Institute of Science and Technology School Corporation
InventorsAkihiro KUSUMI, Peng ZHOU
Estimating the term…
Problem The purpose of the present invention is to provide a novel method for prevention and/or treatment of opioid tolerance or opioid dependence. Specifically, the purpose of the present invention is to develop peptide-based blockers to block MOR-DOR and KOR-DOR heterodimerization. In addition, the purpose of the present invention is to develop homodimer blockers for MOR, DOR, and KOR which modulate their downstream signaling without affecting their internalization. Solution The present invention is a prophylactic and/or therapeutic agent for the prevention and/or treatment of opioid tolerance or opioid dependence comprising the peptide which inhibits the dimer formation of the opioid receptor, wherein the above opioid receptor dimer is a heterodimer or a homodimer formed from one or two opioid receptors selected from the group consisting of the μ type (MOR), the κ type (KOR), and the δ type (DOR).
1-6. (canceled)
A method of prevention and/or treatment of opioid tolerance or opioid dependence comprising administering a peptide which inhibits the formation of heterodimers or homodimers formed from one or two types of opioid receptor selected from the group consisting of the μ-type (MOR), the κ-type (KOR) and the δ-type (DOR) to a subject.
A peptide comprising any one amino acid sequence selected from the group consisting of the amino acid sequences of SEQ ID NOs:
(canceled)
A method of enhancing opioid analgesia comprising administering a peptide which inhibits the formation of heterodimers or homodimers formed from one or two types of opioid receptor selected from the group consisting of the μ-type (MOR), the κ-type (KOR) and the δ-type (DOR) in combination with opioids to a subject who needs to use opioids, who uses opioids, or who plan to use opioids.
Dependencies are inferred from the claim text.