Quinoline compounds as inhibitors of kras

A compound having Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• Y is N or CR6;
• R1 is selected from H, C1-3 alkyl, C1-3 haloalkyl, cyclopropyl, halo, D, CN, and ORa1 ;
• wherein said C1-3 alkyl and cyclopropyl are each optionally substituted with 1 or 2 substituents independently selected from Rg;
• R2 is selected from H, C1-3 alkyl, C1-3 haloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, 5-6 membered heteroaryl-C1-3 alkylene, halo, D, CN, and ORa2;
• wherein said C1-3 alkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, 5-6 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1 or 2 substituents independently selected from Rg;
• Cy1 is selected from C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl and 6-10 membered heteroaryl;
• wherein the 4-10 membered heterocycloalkyl and 6-10 membered heteroaryl each has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S;
• wherein a ring-forming carbon atom of 6-membered heteroaryl and 4-10 membered heterocycloalkyl is optionally substituted by oxo to form a carbonyl group;
• and wherein the C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl and 6-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R10;
• R3 is selected from H, C1-3 alkyl, C1-3 haloalkyl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, C3-6 cycloalkyl-C1-3 alkylene, 4-6 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, 5-6 membered heteroaryl-C1-3 alkylene, halo, D, CN, ORf3, C(O)NRc3Rd3, NRc3Rj3, and NRc3C(O)Rb3;
• wherein said C1-3 alkyl, C3-6cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, C3-6 cycloalkyl-C1-3 alkylene, 4-6 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, and 5-6 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, or 3 substituents independently selected from R30 ;
• R5 is selected from H, C1-3 alkyl, C1-3 haloalkyl, cyclopropyl, halo, D, CN, and ORa5;
• wherein said C1-3 alkyl and cyclopropyl are each optionally substituted with 1 or 2 substituents independently selected from Rg;
• R6 is selected from H, C1-3 alkyl, C1-3 haloalkyl, C3-6 cycloalkyl, 4-9 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, C3-6 cycloalkyl-C1-3 alkylene, 4-6 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, 5-6 membered heteroaryl-C1-3 alkylene, halo, D, CN, ORa6, and C(O)NRc6Rd6;
• wherein said C1-3 alkyl, C3-6 cycloalkyl, 4-9 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, C3-6 cycloalkyl-C1-3 alkylene, 4-6 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, and 5-6 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1 or 2 substituents independently selected from R60;
• R7 is selected from H, C1-3 alkyl, C1-3 haloalkyl, cyclopropyl, halo, D, CN, and ORa7;
• wherein said C1-3 alkyl and cyclopropyl are each optionally substituted with 1 or 2 substituents independently selected from Rg;
• Cy2 is selected from
• wherein n is 0, 1, or 2;
• each R10 is independently selected from C1-3 alkyl, C1-3 haloalkyl, halo, D, CN, ORa10, C(O)Rb10 , C(O)NRc10 Rd10, C(O)ORa10, NRc10Rd10, and S(O)2Rb10;
• each R20 is independently selected from C1-3 alkyl, C1-3 haloalkyl, halo, D, CN, and ORa20;
• each R30 is independently selected from C1-3 alkyl, C1-3 haloalkyl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, D, CN, ORa30, C(O)Rb30, C(O)NRc30Rd30, C(O)ORa30, NRc30Rd30, and S(O)2Rb30;
• wherein said C1-3 alkyl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl are each optionally substituted with 1 or 2 substituents independently selected from R31 ;
• each R31 is independently selected from C1-3 alkyl, C1-3 haloalkyl, halo, D, CN, ORa31, C(O)Rb31, C(O)NRc31Rd31, C(O)ORa31, NRc31Rd31, and S(O)2Rb31;
• each R33 is independently selected from C1-3 alkyl, C1-3 haloalkyl, C3-6 cycloalkyl, 4-membered heterocycloalkyl, 6-membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, D, CN, ORa30, C(O)NRc30Rd30, and NRc30Rd30;
• wherein said C1-3 alkyl, C3-6cycloalkyl, 4-membered heterocycloalkyl, 6-membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl are each optionally substituted with 1 or 2 substituents independently selected from R31 ;
• each R60 is independently selected from C1-3 alkyl, C1-3 haloalkyl, 4-6 membered heterocycloalkyl, 5-6 membered heteroaryl, halo, D, CN, ORa60, C(O)Rb60, C(O)NRc60Rd60 NRc60C(O)Rb60, C(O)ORa60, NRc60C(O)ORa60, NRc60Rd60, NRc60S(O)2Rb60, and S(O)2Rb60;
• wherein said C1-3 alkyl, 4-6 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1 or 2 substituents independently selected from R61;
• each R61 is independently selected from C1-3 alkyl, C1-3 haloalkyl, halo, D, CN, ORa61, and NRc6Rd61 ;
• Ra1 is selected from H, C1-3 alkyl, and C1-3 haloalkyl;
• each Ra2 is independently selected from H, C1-3 alkyl, and C1-3 haloalkyl;
• each Rb3, Rc3 and Rd3 is independently selected from H, C1-3 alkyl, C1-3 haloalkyl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl;
• wherein said, C1-3 alkyl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl are each optionally substituted with 1, 2, or 3 substituents independently selected from R30 or Rc3 and Rd3 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R30 ;
• Rj3 is selected from C1-3 alkyl, C1-3 haloalkyl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl;
• wherein said, C1-3 alkyl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl are each optionally substituted with 1, 2, or 3 substituents independently selected from R30;
• or Rc3 and Rj3 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R30 ;
• Rf3 is selected from C1-3 haloalkyl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl;
• wherein said C1-3 haloalkyl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, or 3 substituents independently selected from R30;
• or
• Rf3 is selected from
• wherein Rx is H or C1-2 alkyl and Ry is C1-2 alkyl;
• or Rx and Ry, together with the C atom to which they are attached, form a 3-, or 4-membered cycloalkyl group;
• Ra5 is selected from H, C1-3 alkyl, and C1-3 haloalkyl;
• each Ra6, Rc6 and Rd6 is independently selected from H, C1-3 alkyl, C1-3 haloalkyl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl;
• wherein said C1-3 alkyl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl are each optionally substituted with 1 or 2 substituents independently selected from R60;
• Ra7 is selected from H, C1-3 alkyl, and C1-3 haloalkyl;
• each Ra10, Rb10, Rc10 and Rd10 is independently selected from H, C1-3 alkyl, and C1-3 haloalkyl;
• each Ra20 is independently selected from H, C1-3 alkyl, and C1-3 haloalkyl;
• Rb20 is selected from NH2, C1-3 alkyl, and C1-3 haloalkyl;
• each Ra30, Rb30, Rc30 and Rd30 is independently selected from H, C1-3 alkyl, and C1-3 haloalkyl;
• each Ra31, Rb31, Rc31 and Rd31 is independently selected from H, C1-3 alkyl, and C1-3 haloalkyl;
• each Ra6, Rb60, Rc60 and Rd60 is independently selected from H, C1-3 alkyl, C1-3 haloalkyl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, and 5-6 membered heteroaryl;
• wherein said C1-3 alkyl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally substituted with 1 or 2 substituents independently selected from R61-or any Rc60 and Rd60 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1 or 2 substituents independently selected from R61;
• and
• each Ra61, Rc61, and Rd61, is independently selected from H, C1-3 alkyl, and C1-3 haloalkyl;
• and
• each Rg is independently selected from D, OH, CN, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino;
• provided that the compound of Formula I is other than,
• 3-(1-((1 R,4R,5S)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-4-ethoxy-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1 H-pyrrolo[3,2-c]quinolin-2-yl)-N,N-dimethylpropanamide.