Microfluidic Devices And Methods For Monitoring Blood Biology Under Flow

A microfluidic device comprising:

• a plurality of microfluidic circuits, each microfluidic circuit comprising:
• an inlet port adapted and configured to receive a fluid sample;
• and
• a microfluidic flow path in fluidic communication with the inlet port, wherein the microfluidic flow paths iteratively converge pairwise to form a converged single microfluidic flow path;
• an outlet channel in fluidic communication with the converged single microfluidic flow path;
• an outlet port in fluidic communication with the outlet channel, the outlet port adapted and configured to collect a fluid sample;
• and
• a priming circuit in fluidic communication with the converged microfluidic flow path and the outlet channel at a single location, such that when a priming fluid is applied under pressure to the priming circuit, the priming fluid flows simultaneously through the microfluidic flow paths to the inlet ports and through the outlet channel to the outlet port.

A microfluidic device comprising:

• a plurality of microfluidic circuits, each microfluidic circuits comprising:
• an inlet port adapted and configured to receive a fluid sample;
• a microfluidic flow path in fluidic communication with the inlet port;
• and
• an outlet in fluidic communication with the microfluidic flow path, the outlet:
• having a smaller cross-sectional area than the microfluidic flow path;
• and
• adapted for communication with a pressure sink;
• and
• a priming circuit in fluidic communication with each of the microfluidic flow paths such that when a priming fluid is applied under pressure to the priming circuit, the priming fluid will flow through the microfluidic flow paths to the inlet ports due to low resistance to laminar flow in the microfluidic flow path relative to the outlet.