Hybrid bioelectronic/engineered cell implantable system for therapeutic agents delivery and applications thereof

A hybrid bioelectronic implantable device containing engineered cells for delivery of therapeutic agents to a subject to treat a medical condition of the subject, the device comprising:

• an implantable device implantable inside the subject's body, wherein the implantable device comprises:
• at least one cell housing containing the engineered cells;
• and
• an optical stimulating system within the at least one cell housing, wherein the optical stimulating system is configured to control production of at least one type of therapeutic agents by the engineered cells;
• wherein the medical condition of the subject comprises one of a sleep disorder, a circadian rhythm disorder, neuro disorders, infertilities, diabetes, obesity, eating disorders, cancers, bone marrow disorders, autoimmune disorders, addictive disorders.

A method for delivering at least one type of therapeutic agents to a subject for treatment of a medical condition by a hybrid bioelectronic implantable device, the method comprising:

• controlling, by a control unit, a light source of an optical stimulating system located in a first cell housing of an implantable device to produce a light of first wavelength, wherein the first cell housing contains a first type of engineered cells having an optogenetic system in each of the engineered cells;
• illuminating the first type of engineered cells with the light of first wavelength for an illumination time period;
• and
• starting production of a first type of therapeutic agent by the engineered cells when the optogenetic systems in the first type of the engineered cells receive the light of first wavelength;
• wherein the medical condition of the subject comprises one of a sleep disorder, a circadian rhythm disorder, neuro disorders, infertilities, diabetes, obesity, eating disorders, cancers, bone marrow disorders, autoimmune disorders, addictive disorders.