Loading patent…
AssigneesRamot at Tel-Aviv University Ltd., Ichilov Tech Ltd.
InventorsTal DVIR, Yahel SHECHTER, Eric SILBERMAN, Aya BARZELAY WOLLMAN, Adiel BARAK
Estimating the term…
A method for reinforcing a cellularized retinal construct fabricated from (i) endothelial cells; (ii) retinal pigment epithelial cells and/or photoreceptors; and (iii) an extracellular matrix (ECM) hydrogel is disclosed. The method comprises contacting the construct with a biocompatible small-molecule reinforcing agent that is capable of chemically interacting with the ECM hydrogel under conditions that maintain viability of the cells, to thereby increase a compressive modulus of the ECM hydrogel by at least 10%.
A method for reinforcing a cellularized retinal construct fabricated from:
A method of generating an engineered cellularized retinal construct comprising:
A cellularized engineered retinal construct comprising endothelial cells and retinal cells distributed within a chemically cross-linked ECM hydrogel, wherein said ECM hydrogel is chemically cross-linked by a biocompatible small-molecule reinforcing agent that is capable of chemically interacting with the ECM hydrogel under conditions that maintain viability of the cells, and wherein a compressive modulus of the ECM hydrogel is higher by at least 50% than a compressive modulus of the ECM hydrogel which is not chemically cross-linked.
Dependencies are inferred from the claim text.