Psma-targeted radioactive metal complex containing nitroaromatic heterocyclic group and preparation method

A prostate-specific membrane antigen (PSMA)-targeted radioactive metal ligand containing a nitroaromatic heterocyclic group, represented by Formula II-1:

• wherein, Chelator2 is a chelating group or a chelator structure for radionuclides, selected from the group consisting of:
• R2 is a nitroaromatic heterocyclic or nitrophenyl group selected from the group consisting of:
• L3 is a linker group between the Chelator2 and a PSMA-targeted group, selected from the group consisting of:
• L4 is a linker group between the Chelator2 and the R2, selected from the group consisting of:
• wherein n is an integer in a range from 0 to 6.

A prostate-specific membrane antigen (PSMA)-targeted radioactive metal complex containing a nitroaromatic heterocyclic group, represented by Formula I-2:

• wherein, Chelator1 is a chelator structure for radionuclides, selected from the group consisting of:
• M is selected from the group comprising:
• 68Ga, 18F—AlF, 177Lu, 90Y, Sc, 225Ac, 212Pb, 64Cu, 161Tb, and 213Bi;
• R1 is a nitroaromatic heterocyclic or nitrophenyl group selected from the group consisting of:
• L1 is a linker group between the Chelator1 and a PSMA-targeted group, selected from the group consisting of:
• L2 is a linker group between the Chelator1 and the R1, selected from the group consisting of:
• wherein n is an integer in a range from 0 to 6.

A prostate-specific membrane antigen (PSMA)-targeted radioactive metal complex containing a nitroaromatic heterocyclic group, represented by Formula II-1:

• wherein, Chelator2 is a chelating group or a chelator structure for radionuclides, selected from the group consisting of:
• M is selected from the group comprising:
• 68Ga, 18F—AlF, 177Lu, 90Y, Sc, 225Ac, 212Pb, 64Cu, 61Tb, and 213Bi;
• R2 is a nitroaromatic heterocyclic or nitrophenyl group selected from the group consisting of:
• L3 is a linker group between the Chelator2 and a PSMA-targeted group, selected from the group consisting of:
• L4 is a linker group between the Chelator2 and the R2, selected from the group consisting of:
• wherein n is an integer in a range from 0 to 6.