Small molecule drug-oligonucleotide conjugate and use thereof
AssigneesShanghai Jiao Tong University, Zhejiang Yimou Biology Science and Technology Co., Ltd
InventorsChuan ZHANG, Ruihua ZHU, Yangyang HUANG
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Abstract
Disclosed is a small molecule drug-oligonucleotide conjugate and use thereof, which belongs to the technical field of biomedical technology. In order to solve the problems of poor water solubility and difficulty in drug delivery of the existing small molecule immunomodulatory drug, the small molecule immunomodulatory drug is coupled with an oligonucleotide drug.
Claims21
A small molecule drug-oligonucleotide conjugate, wherein the small molecule drug-oligonucleotide conjugate is prepared by covalent coupling of a small molecule drug with an immunomodulatory function and a functional oligonucleotide molecule capable of regulating expression of an inflammation-related gene.
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Dependencies are inferred from the claim text.