Viscosity-reducing excipient composition and low-viscosity highly concentrated protein formulation containing same

Abstract

Disclosed are an excipient composition for reducing the viscosity of protein pharmaceuticals and a low-viscosity, high-concentration protein composition formulation containing the same which have a remarkably low viscosity at a high protein concentration of about 20% or more, are convenient to manufacture, store, and use, and are particularly useful for the preparation of injections for antibody treatment for subcutaneous administration and intramuscular administration. In particular, the high-concentration protein formulation can be advantageously used immediately after storage without separate preheating because it maintains low viscosity even when stored at low temperature.

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