Cd38 modulating antibody agents

An anti-human CD38 antibody or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof each comprises:

• SEQ ID NO:
• 3 as variable heavy chain complementarity determining region 3, SEQ ID NO:
• 1 as variable heavy chain complementarity determining region 1, SEQ ID NO:
• 2 as variable heavy chain complementarity determining region 2, SEQ ID NO:
• 5 as variable light chain complementarity determining region 1, SEQ ID NO:
• 6 as variable light chain complementarity determining region 2;
• and
• a sequence selected from SEQ ID NO:
• 10, SEQ ID NO:
• 11, SEQ ID NO:
• 12, and SEQ ID NO:
• 13 as variable light chain complementarity determining region 3.