Microbiota analogs of tumor associated antigens and uses thereof
AssigneeIstituto Nazionale Tumori Irccs - Fondazione G. Pascale
InventorsLuigi BUONAGURO, Maria TAGLIAMONTE, Angela MAURIELLO, Beatrice CAVALLUZZO, Concetta RAGONE, Carmen MANOLIO
Life of this patent
Estimating the term…
Abstract
The present invention relates to tumor antigens and their use in cancer immunotherapy. In particular, the present invention relates to the identifications of microbiota sequence analogs of tumor associated antigenic epitope sequences which can be used in tumor vaccination therapies in the treatment and prevention of cancer and have a significant impact on cancer progression and prognosis.
Claims30
A composition comprising a peptide derived from the human microbiota and a pharmaceutically acceptable excipient, wherein said at least one peptide comprises a core sequence of 9 amino acids wherein said core sequence has 6, 7 or 8 amino acids identical and in the same position with respect to the tumor-associated antigenic epitope sequence GLYDGMEHL (SEQ ID No 1) and the remaining amino acids are different with respect to the amino acids in the same position of said epitope sequence.
(canceled)
A composition comprising a peptide derived from the human microbiota and a pharmaceutically acceptable excipient, wherein said peptide comprises a core sequence of 9 amino acids wherein said core sequence has 6, 7 or 8 amino acids identical and in the same position with respect to one tumor-associated antigenic epitope sequence selected from the group consisting of:
- (SEQ ID No. 2)
- KVAELVHFL;
- (SEQ ID No 3)
- FLWGPRALV;
- (SEQ ID No 4)
- VLPDVFIRV;
- (SEQ ID No 5)
- KVLEYVIKV;
- (SEQ ID No 6)
- KVVEFLAML;
- (SEQ ID No 7)
- ALKDVEERV;
- (SEQ ID No 8)
- KASEKIFYV;
- (SEQ ID No 9)
- NYNNFYRFL;
- (SEQ ID No 10)
- EYLSLSDKI;
- (SEQ ID No 11)
- EYLQLVFGI;
- and
- (SEQ ID No 12)
- LYATVIHDI.
- and remaining amino acids are different with respect to the amino acids in the same position of said tumor-associated antigenic epitope sequence.
(canceled)
A dietary supplement or replacement comprising a peptide derived from the human microbiota, wherein said peptide comprises a core sequence of 9 amino acids wherein said core sequence has 6, 7 or 8 amino acids identical and in the same position with respect to the tumor-associated antigenic epitope sequence GLYDGMEHL (SEQ ID No 1) and the remaining amino acids are different with respect to the amino acids in the same position of said epitope sequence.
A dietary supplement or replacement comprising a peptide derived from the human microbiota, wherein said peptide comprises a core sequence of 9 amino acids wherein said core sequence has 6, 7 or 8 amino acids identical and in the same position with respect to one tumor-associated antigenic epitope sequence selected from the group consisting of:
- (SEQ ID No. 2)
- KVAELVHFL;
- (SEQ ID No 3)
- FLWGPRALV;
- (SEQ ID No 4)
- VLPDVFIRV;
- (SEQ ID No 5)
- KVLEYVIKV;
- (SEQ ID No 6)
- KVVEFLAML;
- (SEQ ID No 7)
- ALKDVEERV;
- (SEQ ID No 8)
- KASEKIFYV;
- (SEQ ID No 9)
- NYNNFYRFL;
- (SEQ ID No 10)
- EYLSLSDKI;
- (SEQ ID No 11)
- EYLQLVFGI;
- and
- (SEQ ID No 12)
- LYATVIHDI.
- and remaining amino acids are different with respect to the amino acids in the same position of said tumor-associated antigenic epitope sequence.
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.