Oral pharmaceutical composition for prevention or treatment of osteoporosis containing teriparatide and method for preparation thereof

Abstract

The present disclosure relates to an oral pharmaceutical composition for the prevention and treatment of osteoporosis comprising an ion-binding complex including a teriparatide, an L-lysine-linked deoxycholic acid, a deoxycholic acid, and an alkyl glycoside-based surfactant. According to the present disclosure, the ion-binding complex including teriparatide according to the present disclosure can maintain the drug at a high dose by inhibiting its degradation by peptidases in the gastrointestinal tract due to the incorporation of teriparatide into the micellar structure and can improve the permeability of the drug due to the availability of various transmembrane absorption routes, which ultimately increases the oral bioavailability of the drug, teriparatide.

Dependencies are inferred from the claim text.