Back to results
US 2025/0367265 A1Published application
Pharmaceutical parenteral composition of dual glp1/2 agonist
AssigneeZealand Pharma A/S
InventorsLise Giehm, Alistair Vincent Gordon Edwards
Life of this patent
Estimating the term…
Abstract
The present invention relates to pharmaceutical compositions suitable for parenteral administration in human subjects. In particular, the present invention relates to isotonic pharmaceutical compositions for parenteral administration.
Claims27
An isotonic parenteral pharmaceutical composition, comprising:
- a. at least about 1 mg/mL of one or more GLP-1/GLP-2 dual agonist wherein the one or more GLP-1/GLP-2 dual agonist is Hy-H[Aib]EGSFTSELATILD[K([17-carboxy-heptadecanoyl]-isoGlu)]QAARDFIAWLIQHKITD-OH (CPD1OH) (SEQ ID NO:
- 1) or a pharmaceutically acceptable salt thereof:
- b. about 1 mM to about 200 mM of buffer component;
- and
- c. about 1 mM to about 500 mM of one or more tonicity agent,
- wherein said one or more tonicity agent comprises or a non-ionic tonicity agent, wherein the non-ionic tonicity agent is mannitol
- wherein said composition further comprises a solvent, and
- wherein said composition has a pH of about pH 6.0 to about pH 8.2.
5 more elements
3-6. (canceled)
(canceled)
(canceled)
16-19. (canceled)
(canceled)
23-29. (canceled)
33-36. (canceled)
The isotonic parenteral pharmaceutical composition according to claim 39, wherein the composition has a pH of about pH 7.0 to about pH 8.0.
Dependencies are inferred from the claim text.