Glp-1 analogue compositions and preparation method
OwnerLuis Gómez COELLO, Jamie Osuna LÓPEZinventors
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Abstract
Disclosed herein is a method for the preparation of a pharmaceutical composition comprising a GLP-1 agonist, a tonicity modifier, a buffering agent and a preservative which comprises the following steps: preparing a final solution comprising the tonicity modifier, the buffering agent, the preservative, the GLP-1 agonist and water for injection; and adjusting the pH of the final solution between 7.5-8.5 with a pH adjuster; wherein the final solution is prepared at a temperature between 2-15° C.
Claims20
A method for the preparation of a pharmaceutical composition comprising a GLP-1 agonist, a tonicity modifier, a buffering agent, and a preservative which comprises the following steps:
- a. preparing a final solution comprising the tonicity modifier, the buffering agent, the preservative, the GLP-1 agonist and water for injection;
- and
- b. adjusting the pH of the final solution between 6.5-8.5, with a pH adjuster;
- wherein the final solution is prepared at a temperature between 2-15° C.
Dependencies are inferred from the claim text.