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AssigneeThe Regents of the University of California
InventorsNasim Annabi, Avijit Baidya
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A neurotransmitter moiety, dopamine, was chemically modified with a nitro-group to explore its influence on synthesizing a multifunctional biomaterial for therapeutic applications. Chemically, by manipulating the aromatic-electron density. while nitro-group prevented the self-oxidation of catecholic domain. this facilitated the aromatic suturing of nitrocatechol moieties, forming a novel macromolecular structure. Incorporation of the sutured-nitrocatecholic moieties in a gelatin-based hydrogel introduced extended pi-electron delocalization mediated electroconductive microenvironment and maintained its adhesive properties originated from the catecholic domains, forming a multi-functional bioadhesive for tissue repairing. Embodiments of the invention include engineered hydrogels enriched with multi-mode noncovalent interactions and excellent mechano-physical properties that are useful for diverse biomedical applications.
A composition of matter comprising a hydrogel and a polymer comprising dopamine having a nitro (NO2) moiety coupled to an aromatic ring (“nDopa”).
A method of making a hydrogel composition comprising sutured-nitrocatecholic dopamine polymers, the method comprising combining together a hydrogel and polymers comprising a polymeric backbone comprising nDopa disposed on the polymeric backbone so as to facilitate chemical suturing of aromatic domains of nDopa molecules;
Dependencies are inferred from the claim text.