FOLIC ACID-MODIFIED LIPOSOME-ENCAPSULATED TILIANIN NANOCRYSTAL (FA-Lipo@Til NC), PREPARATION METHOD AND USE THEREOF

Abstract

A folic acid-modified liposome-encapsulated tilianin nanocrystal (FA-Lipo@Til NC), and a preparation method and use thereof are provided. The FA-Lipo@Til NC includes a tilianin nanocrystal (Til NC) composition and a folic acid-modified phospholipid (FA-Lipo) bilayer encapsulated on a surface of the Til NC; where raw materials of the FA-Lipo bilayer include phospholipid, cholesterol (Chol), a methoxy poly(ethylene glycol)-cholesterol conjugate (mPEG-Chol), and a folic acid (FA) compound. The FA-Lipo@Til NC has a high drug loading capacity and a desirable stability. The inhibition of a Til dissolution behavior improves a penetration efficiency of the Til NC composition in intestinal mucus and an affinity with intestinal epithelial cells, thus effectively improving bioavailability of the Til.

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