Bicyclic compounds and methods for their use in treating pitt hopkins syndrome
AssigneeNeuren Pharmaceuticals Limited
InventorsPatricia COGRAM, Jonathan PILCHER, Lawrence Irwin GLASS
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Abstract
Embodiments of this invention provide compounds, compositions, methods, and uses for therapeutic diketopiperazines, including cyclic G-2-Allyl Proline and other cyclic Glycyl Proline compounds to treat Pitt Hopkins Syndrome and symptoms thereof, as well as manufacture of compositions, medicaments including tablets, capsules, liquid formulations, gels, injectable solutions, and other formulations that are useful for treatment of such conditions.
Claims22
A method for treating a mammal having Pitt Hopkins Syndrome, comprising administering to the mammal, a compound having the formula:
- or a pharmaceutically acceptable salt or hydrate thereof, wherein
- X1 is selected from the group consisting of NR′, O and S;
- X2 is selected from the group consisting of CH2, NR′, O and S;
- R1, R2, R3, R4 and R5 are independently selected from the group consisting of —H, —OR′, —SR′, —NR′R′, —NO2, —CN, —C(O) R′, —C(O) OR′, —C(O) NR′R′, —C(NR′) NR′R′, trihalomethyl, halogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl and substituted heteroarylalkyl;
- each R′ is independently selected from the group consisting of —H, alkyl, heteroalkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl;
- or R4 and R5 taken together are —CH2—(CH2)n—CH2— where n is an integer from 0-6;
- or R2 and R3 taken together are —CH2—(CH2)n—CH2— where n is an integer from 0-6.
A composition for treating a symptom of Pitt Hopkins Syndrome in a mammal suffering from such a disorder, comprising a compound having the formula:
- or a pharmaceutically acceptable salt or hydrate thereof, wherein
- X1 is selected from the group consisting of NR′, O and S;
- X2 is selected from the group consisting of CH2, NR′, O and S;
- R1, R2, R3, R4 and R5 are independently selected from the group consisting of —H, —OR′, —SR′, —NR′R′, —NO2, —CN, —C(O) R′, —C(O) OR′, —C(O) NR′R′, —C(NR′) NR′R′, trihalomethyl, halogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl and substituted heteroarylalkyl;
- each R′ is independently selected from the group consisting of —H, alkyl, heteroalkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl;
- or R4 and R5 taken together are —CH2—(CH2)n—CH2— where n is an integer from 0-6;
- or R2 and R3 taken together are —CH2—(CH2)n—CH2— where n is an integer from 0-6.
19-34. (canceled)
(canceled)
Dependencies are inferred from the claim text.