Method for inducing in-situ regeneration of mammal and use thereof
AssigneesInstitute of Zoology, Chinese Academy of Sciences, Beijing Institute for Stem Cell and Regenerative Medicine
InventorsWei LI, Qi ZHOU, Zheng-Quan HE, Xuewei YUAN, Zongbao LU, Xin WANG, Shuai WANG, Yufei LI, Liu WANG
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Abstract
Provided is use of a protein synthesis inhibitor in promoting regeneration and repair capacity of mammal tissues or complex structures or organs. The protein synthesis inhibitor is a small molecule compound, from any of cycloheximide or an Amaryllidaceae extract, capable of promoting regeneration of mammal tissues and organs.
Claims19
Use of a protein synthesis inhibitor or a composition comprising the protein synthesis inhibitor in the promotion of regeneration and repair capacity of a tissue, complex structure or organ of a mammal or in the treatment of a disease related to regeneration and repair of a tissue, complex structure or organ of a mammal.
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A composition, wherein it comprises a protein synthesis inhibitor, an all-trans retinoic acid and a BMP activator, preferably the protein synthesis inhibitor is cycloheximide (CHX) or Narciclasinee, and the BMP activator is BMP signaling agonist sb4.
A method for promoting regeneration and repair of a tissue, complex structure or organ of a mammal, comprising administering a protein synthesis inhibitor or a composition comprising the protein synthesis inhibitor to a subject in need thereof.
Dependencies are inferred from the claim text.