Topical angiotensin ii receptor blockers (arbs) for treating eye conditions

A method comprising:

• delivering a system to a subject with an eye condition,
• wherein said eye condition is selected from:
• i) a corneal scarring fibrosis, ii) a transforming growth factor beta-induced (TGFBI) corneal dystrophy, iii) a conjunctival fibrotic disease, iv) an intraocular fibrotic disease, and v) a conjunctival bleb scarring and/or shunt encapsulation, and
• wherein said system comprises:
• a) an eye dropper container or a contact lens, and
• b) a composition comprising:
• i) a drug agent, wherein said drug agent comprises an ACE-2 receptor antagonist.

A composition comprising:

• a) a drug agent, wherein said drug agent comprises an ACE-2 receptor antagonist, and wherein said drug agent is present in said composition at a concentration of 0.01-0.09 or 2.3-100 mg/ml;
• b) water, and
• c) at least one of the following:
• i) one or more salts present at a level such that said composition, when in aqueous form, has about a physiological concentration of said one or more salts and about a physiological pH;
• ii) one or more gelling agents present at a level such that said composition is in the form of a gel;
• and
• iii) one or more ointment forming agents, present at a level such that said composition is in the form of an ointment;
• d) optionally a preservative, and
• e) optionally a soothing agent.

A system comprising:

• a) composition comprising:
• i) a drug agent, wherein said drug agent comprises an ACE-2 receptor antagonist present in said composition at a concentration of 0.01-0.09 or 2.3-100 mg/ml;
• ii) water, and
• iii) at least one of the following:
• A) one or more salts present at a level such that said composition, when in aqueous form, has about a physiological concentration of said one or more salts and about a physiological pH;
• B) one or more gelling agents present at a level such that said composition is in the form of a gel;
• and
• C) one or more ointment forming agents, present at a level such that said composition is in the form of an ointment;
• iv) optionally a preservative, and
• v) optionally a soothing agent;
• and
• b) an eye dropper container or a contact lens.