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US 2025/0367168 A1Published application
Orally disintegrated tablet comprising carbamate compound
AssigneeSK Biopharamaceuticals Co., Ltd
InventorsMyoung Ki BAEK, So Young CHOI, Ji Hye LEE
Life of this patent
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Abstract
The present invention relates to an orally disintegrated tablet and a method for producing same, the tablet containing a carbamate compound of chemical formula 1, an isomer thereof, or a pharmaceutically acceptable salt, a solvate or a hydrate thereof, as an active ingredient.
Claims13
-24. (canceled)
A method for treating a disorder, comprising:
- administering to a subject in need thereof an orally disintegrating tablet which comprises:
- (i) a granule prepared by wet granulation to comprise the following ingredients:
- (1) a carbamate compound of the following Formula 1, an isomer thereof, or a pharmaceutically acceptable salt, solvate or hydrate thereof as an active ingredient;
- (2) a hydrophilic excipient consisting of a first hydrophilic excipient of a sugar alcohol;
- and a second hydrophilic excipient selected from the group consisting of starch, microcrystalline cellulose, hydroxypropylcellulose and lactose;
- and
- (3) a disintegrant;
- and
- (ii) a disintegrant which is mixed with the granule of (i):
- wherein,
- R1 and R2 are each independently selected from the group consisting of hydrogen, halogen, C1-C8 alkyl, halo-C1-C8 alkyl, C1-C8 thioalkoxy and C1-C8 alkoxy;
- and
- one of A1 and A2 is CH, and the other is N,
- wherein the disorder is selected from the group consisting of anxiety, depression, convulsion, epilepsy, migraine, bipolar disorder, drug abuse, smoking, attention deficit hyperactivity disorder (ADHD), obesity, sleep disorders, neuropathic pain, stroke, cognitive disorders, neurodegeneration and muscle spasm.
11 more elements
A method for treating a disorder, comprising:
- administering to a subject in need thereof an orally disintegrating tablet which is prepared by a method comprising:
- (a) a step of mixing the following ingredients (1) to (3);
- (1) a carbamate compound of the following Formula 1, an isomer thereof, or a pharmaceutically acceptable salt, solvate or hydrate thereof as an active ingredient;
- (2) a hydrophilic excipient consisting of a first hydrophilic excipient of a sugar alcohol;
- and a second hydrophilic excipient selected from the group consisting of starch, microcrystalline cellulose, hydroxypropylcellulose and lactose;
- and
- (3) a disintegrant;
- (b) a step of preparing a granule by wet granulation using the mixture of step (a);
- (c) a step of mixing the granule obtained from step (b) with a disintegrant;
- and
- (d) a step of lubricating and tableting the mixture obtained from step (c):
- wherein,
- R1 and R2 are each independently selected from the group consisting of hydrogen, halogen, C1-C8 alkyl, halo-C1-C8 alkyl, C1-C8 thioalkoxy and C1-C8 alkoxy;
- and
- one of A1 and A2 is CH, and the other is N,
- wherein the disorder is selected from the group consisting of anxiety, depression, convulsion, epilepsy, migraine, bipolar disorder, drug abuse, smoking, attention deficit hyperactivity disorder (ADHD), obesity, sleep disorders, neuropathic pain, stroke, cognitive disorders, neurodegeneration and muscle spasm.
13 more elements
Dependencies are inferred from the claim text.