Next generation diprovocims that activate the innate and adaptive immune response

A compound of Formula I, wherein

• R1, R2 and R3 are the same or different and are a trans-2-phenylcyclopropyl, or a trans-2-(4-fluorophenyl)cyclopropyl group, and
• R4 is a composite of (a) a hydrocarbyl group bonded to the depicted amido nitrogen atom and (b) a substituent group bonded thereto as discussed below, the hydrocarbyl group has a longest chain of atoms that has a total length that is about that of a saturated chain of about 2 carbon atoms (an ethylene group), and a length that is less than that of a saturated chain of about 20 carbon atoms [an eicosylene group],
• said hydrocarbyl group including a methylene group (—CH2—) that is 1) bonded directly to or 2) bonded indirectly and distal to the amido nitrogen of the depicted —C(O)NH—R4 group,
• and said methylene group is also bonded to a substituent group that is one or another of i) a phenyl group that includes a substituent selected from the group consisting of a hydroxyl, amino, carboxy, C1-C6 alkyl carboxylate, sulfo, C1-C6 alkyl sulfonate, fluoro, azido and an ethynyl group, ii) a hydroxyl, a mercaptan, amine, mono- or disubstituted amine, an azido group or iii) to an oxygen, nitrogen or sulfur atom that is part of a substituent group that is selected from the group consisting of an amino acid, ether, ester, carbonate, carbamate, thioether, thioester, thiourea, amido, mono- or disubstituted amide, urea, and a N′-mono or N′,N′-disubstituted urea, wherein said substituent group contains a chain of atoms that include zero to four oxygens, zero to two sulfur atoms, and zero to four nitrogen atoms, with the proviso that the sum of the sulfur, nitrogen and oxygen atoms in the substituent is at least one, and not greater than eight, and
• the length of said hydrocarbyl group together with the substituent bonded to said methylene of that hydrocarbyl group is less than that of a saturated chain of about 24 carbon atoms [a tetracosylene group].