Compositions And Methods For Prevention And Reduction Of Traumatic Brain Injury
OwnerRob D. Dickermaninventor
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Abstract
Compositions and methods are presented that, upon administration prior to trauma, are effective to prevent and/or reduce severity of sequelae of TBI upon trauma. Advantageously, the compositions presented herein can be orally administered, have an excellent safety profile, and will not require a prescription by physician or hospital admission. Further contemplated compositions and methods are presented to be effective to prevent and/or reduce severity of sequelae of glutamate excitotoxicity.
Claims20
A pharmaceutically acceptable composition for neuroprotection against glutamate excitotoxicity, comprising:
- i) a branched chain amino acid (BCAA) component comprising leucine, valine, and isoleucine, wherein the leucine, valine, and isoleucine are present at a weight ratio of X:1:1, with X being between 2-4;
- and
- ii) a vitamin component comprising vitamin B7 and at least one vitamin selected from the group consisting of vitamin C, vitamin B3, vitamin B5, vitamin B6, vitamin B9, and vitamin B12;
- wherein the composition is formulated for intravenous administration and is effective in preventing or reducing sequelae of the glutamate excitotoxicity.
A method of providing neuroprotection to prevent or reduce sequelae of glutamate excitotoxicity in a subject, the method comprising:
- administering to the subject an intravenous pharmaceutical composition comprising:
- i) a branched chain amino acid (BCAA) component comprising leucine, valine, and isoleucine, wherein the leucine, valine, and isoleucine are present at a weight ratio of X:1:1, with X being between 2-4;
- and
- ii) a vitamin component comprising vitamin B7 and at least one vitamin selected from the group consisting of vitamin C, vitamin B3, vitamin B5, vitamin B6, vitamin B9, and vitamin B12
- wherein the administration of the composition prevents or reduces sequelae associated with glutamate excitotoxicity.
Dependencies are inferred from the claim text.