Methods for treating cancer
AssigneeRadius Pharmaceuticals, Inc.
InventorGary HATTERSLEY
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Abstract
Disclosed herein are methods of treating one or more tumors by administering to the subject a therapeutically effective amount of a combination of RAD1901 or solvates (e.g., hydrate) or salts thereof and one or more second therapeutic agent(s) (e.g., everolimus). The cancer is an estrogen-dependent cancer, such as breast cancer, ovarian cancer, colon cancer, endometrial cancer, or prostate cancer.
Claims43
A method of inhibiting tumor growth or producing tumor regression in a subject having a drug-resistant estrogen receptor alpha-positive cancer comprising administering to said subject a therapeutically effective amount of a combination of everolimus and RAD1901 having the structure:
- or a salt or solvate thereof.
A method of inhibiting tumor growth or producing tumor regression in a subject having a mutant estrogen receptor alpha-positive cancer comprising administering to said subject a therapeutically effective amount of a combination of everolimus and RAD1901 having the structure:
- or a salt or solvate thereof.
A pharmaceutical composition comprising everolimus and RAD1901 or a salt or solvate thereof.
A method of treating breast cancer in a subject having a drug-resistant estrogen receptor alpha-positive cancer comprising administering to said subject a therapeutically effective amount of a combination of an m-TOR inhibitor and RAD1901 having the structure:
- or a salt or solvate thereof.
Dependencies are inferred from the claim text.