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US 2025/0367138 A1Published application
Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and methylglyoxal
AssigneeNovocure GmbH
InventorMaximilian SCHEER
Life of this patent
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Abstract
Compositions, systems, and methods for reducing viability of cancer cells and treating cancer, as well as preventing an increase of volume of a tumor present in a body of a living subject, are disclosed. Also disclosed are methods of enhancing cytotoxicity of MGO against cancer cells. The systems and methods involve application of an alternating field in combination with administration of at least one composition comprising methylglyoxal (MGO).
Claims20
A method of reducing viability of cancer cells, the method comprising the steps of:
- (1) administering at least one composition to the cancer cells, wherein the at least one composition comprises methylglyoxal (MGO);
- and
- (2) applying an alternating electric field to the cancer cells for a period of time.
A method of treating cancer in a subject, the method comprising the steps of:
- (1) administering at least one composition to the subject, wherein the at least one composition comprises methylglyoxal (MGO);
- and
- (2) applying an alternating electric field to a target region of the subject.
A system, comprising:
- an alternating electric field-generating device;
- and
- at least one composition comprising methylglyoxal.
Dependencies are inferred from the claim text.