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US 2025/0367133 A1Published application
Polymer nanoparticle compositions for non-viral gene delivery
OwnerAshlee J. Colbert, Emma K. Schmitz +3inventors
InventorsAshlee J. Colbert, Emma K. Schmitz, Kenneth R. Sims, JR., Andrea D. McCue, Allison Secard
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Abstract
The disclosure relates to block copolymer nanoparticles for therapeutic delivery of nucleotides, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering miRNAs.
Claims20
A block copolymer comprising a first block and a second block, wherein:
- the first block comprises a homopolymer of poly (2-dimethylaminoethyl methacrylate) p(DMAEMA) or poly (2-aminoethyl methacrylamide) p(AEMA);
- and
- the second block comprises either:
- (i) a homopolymer of poly (butylmethacrylate) p (BMA) or a homopolymer of poly (2-hydroxyethylmethacrylate) p(HEMA);
- or
- (ii) a copolymer comprising at least two monomer units selected from DMAEMA, BMA, and diethylacrylamide (DEAAM).
3 more elements
Dependencies are inferred from the claim text.