Lipid Compounds and Uses Thereof

A compound of Formula (I)

• or a pharmaceutically acceptable salt, N-oxide, tautomer, or stereoisomer thereof, wherein
• m, n, o, and p are each independently 1-3;
• G1 is C1-12alkylene or C2-12alkenylene;
• R1 is —N(R2)R3, —OR4, CN, —N(R4)(heteroaryl), —O(CH2)qOH, —(OCH2CH2)rOH, —OC(═O)R5, —N(R4)C(═O)R5, —N(R4)S(O)2R5, —N(R4)C(═O)N(R2)R3, —OC(═O)N(R2)R3, —N(R4)C(═O)OR5, —N(R4)C(═S)N(R2)R3, —N(R4)C(═NR6)N(R2)R3, or
• R2 and R3 are each independently H, C1-6alkyl, C3-8cycloalkyl, or aryl;
• or R2 and R3 together with the nitrogen atom to which they are attached form a heterocyclic ring;
• R4 is H, C1-6alkyl or C3-8cycloalkyl;
• R5 is C1-6alkyl or C3-8cycloalkyl optionally substituted by C1-6alkyl;
• R6 is H, CN, NO2, C1-6alkyl, OR5, S(O)2R5, or S O)2N(R2)R3;
• q is 2-6;
• r is 1-6;
• W is
• X is N or CH;
• G2 and G3 are each independently C1-12alkylene or C2-12alkenylene;
• L1 and L2 are each independently —C(═O)OR7, —OC(═O)R7, —OC(═O)(CH2)rC(═O)OR7, —OC(═O)(CH2)rOC(═O)R7, —OC(═O)N(R4)R7, —N(R4)C(═O)OR7, —N(R4)C(═O)N(R4)R7, —OC(═O)OR7, or —S—SR7;
• and
• R7 is C6-24alkyl, C6-24alkenyl, or C6-24alkynyl where each is optionally substituted by F, C1-6alkoxy, C3-8cycloalkyl, or C3-8cycloalkenyl, wherein the R7 of L1 and L2 may be the same or different.