Delivery of sustained local and systemic immunomodulation
AssigneesNortheastern University, The Brigham and Women's Hospital, Inc.
InventorsNeeda Brown, Srinivas Sridhar, Jennifer Lynn Guerriero, Alexander P. Gottieb
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Abstract
Disclosed are sustained biodegradable implant (a depot) that releases high drug doses directly into the tumor for treating cancer. The depot comprises a biodegradable polymer and a STING agonist and/or a PARP inhibitor (PARPi); wherein the STING agonist or the PARPi is distributed in the biodegradable polymer. The depot activates anticancer innate and adaptive immunity within the tumor microenvironment and promote immune infiltration of secondary, metastatic sites.
Claims22
A depot, comprising a biodegradable polymer and a STING agonist or a PARP inhibitor (PARPi);
- wherein the STING agonist or the PARPi is distributed in the biodegradable polymer.
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-42. (canceled)
Dependencies are inferred from the claim text.