Devices, systems, and methods for improved bone remodeling
OwnerRobert Z. Tashjian, Peter N. Chalmers +3inventors
InventorsRobert Z. Tashjian, Peter N. Chalmers, T. Wade Fallin, James M. Hotaling, Austin M. Hickey
Life of this patent
Estimating the term…
Abstract
Disclosed are devices and methods for providing local administration of a sex hormone composition in a mammalian body to promote bone remodeling. The device includes an implantable structure configured for placement at a target intraosseous and/or periosteal site in the mammalian body and an effective amount of a sex hormone composition associated with the implantable structure. The sex hormone composition comprises both an estrogen and an androgen.
Claims25
A device for providing local administration of a sex hormone composition in a mammalian body to promote bone remodeling, the device comprising:
- an implantable structure configured for placement at an intraosseous and/or periosteal target site in the mammalian body;
- and
- an effective amount of a sex hormone composition associated with the implantable structure, the sex hormone composition comprising both an estrogen and an androgen, both of which are included in the implantable structure,
- wherein the device omits other growth factors, and
- wherein the device is configured such that the sex hormone composition elutes from the implantable structure under physiological conditions to provide local administration of the sex hormone composition.
A device for providing local administration of a sex hormone composition in a mammalian body to promote bone remodeling, the device comprising:
- an implantable structure configured for placement at an intraosseous and/or periosteal target site in the mammalian body;
- and
- an effective amount of a sex hormone composition associated with the implantable structure, the sex hormone composition comprising both an estrogen and an androgen,
- wherein the device is configured such that the sex hormone composition elutes from the implantable structure under physiological conditions to provide local administration of the sex hormone composition, and
- wherein the device is specifically configured for a male subject or a female subject,
- (i) wherein when the device is configured for a male subject, the sex hormone composition comprises a ratio of androgen to estrogen of at least 10:1 and optionally up to 20:1,
- (ii) wherein when the device is configured for a female subject, the sex hormone composition comprises a ratio of androgen to estrogen of at least 1:3 and optionally up to 1:5.
(canceled)
(canceled)
Dependencies are inferred from the claim text.