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AssigneeCsl Behring (Australia) Pty Ltd
InventorsKarl MCCANN, Zhenghui XU, Per HANSEN, Jiaxi ZHANG
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A method (100) of filtering solids (41) from a solution (44) derived from blood plasma is disclosed. The method (100) comprises feeding (102) the solution (44) into a hollow fibre filter (12) at a feed rate, the hollow fibre filter (12) comprising a plurality of hollow fibres (38), each hollow fibre (38) comprising a membrane (36) defining an elongate hollow fibre channel (32). The method (100) further comprises filtering (104) the solution (44) using the hollow fibre filter (12) to produce a permeate (46) and a retentate (45), the permeate (46) passing through pores (37) of the membrane (36) at a trans-membrane pressure and the retentate (45) flowing from respective outlets of the elongate hollow fibre channels (32), wherein the permeate (46) has a reduced solids content with respect to the solution (44) fed into the hollow fibre filter (12).
A method of filtering solids from a solution derived from blood plasma, the method comprising:
The method of any one of the preceding claims, wherein the pores of the membrane have an average pore size of from about 0.1 microns to about 4 micron.
The method of any one of the preceding claims, wherein the trans-membrane pressure is from about 20 kilopascals to about 300 kilopascals.
The method of any one of the preceding claims, further comprising measuring a permeate flux during filtering.
The method of any one of the preceding claims, wherein the method comprises multiple filtering steps, and wherein the method further comprises feeding a backwash solution through the hollow fibre filter between filtering steps.
The method of any one of the preceding claims, wherein the solution has a conductivity of about 2 mS/cm to about 40 mS/cm.
The method of any one of the preceding claims, wherein the solution has a conductivity of about 8 mS/cm to about 15 mS/cm.
The method of any one of the preceding claims, wherein the solution is at a temperature of from about 4° C. to about 37° C.
The method of any one of the preceding claims, wherein the solution comprises a blood plasma fraction.
The method of any one of the preceding claims, wherein the solution comprises a buffer.
The method of any one of the preceding claims, wherein the solution comprises hemopexin.
The method of any one of the preceding claims, wherein the solution comprises a filter aid.
The method of any one of the preceding claims, wherein the solution has a pH of between about 4 and about 9.
The method of any one of the preceding claims, wherein a recovery of the permeate is at least 30%.
The method of any one of the preceding claims, wherein a recovery of the permeate is at least 50%.
The method of any one of the preceding claims, wherein a recovery of the permeate is at least 75%.
The method of any one of the preceding claims, wherein a recovery of the permeate is at least 90%.
The method of any one of the preceding claims, wherein a turbidity of the permeate is less than about 400 nephelometric turbidity units.
A blood plasma product produced using the method of any one of the preceding claims.
Dependencies are inferred from the claim text.