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US 2025/0353815 A1Published application
AMINO ACID HAVING FLUORINE AT a-POSITION, AND DERIVATIVE OF SAME
AssigneesSynCrest Inc., University of the Ryukyus
InventorsPengyu XU, Shin YONEYAMA, Satoru ARIMITSU, Riko GENKA
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Abstract
A first object of the present invention is to provide an amino acid compound having the α-position fluorinated by fluorinating the α-position with high yields. A second object of the present invention is to provide an amino acid compound having the α-position fluorinated by fluorinating the α-position with high enantioselectivity. Provided are amino acids having fluorine at the α-position and their derivatives.
Claims6
A fluorinated amino acid compound represented by formula (1):
- wherein
- R represents an alkyl group, an alkoxy group, an aryl group, an ester group, an aralkyl group, an alkenyl group, or an alkynyl group, and
- Nphth represents an N-phthaloyl group:
A method for producing a fluorinated amino acid compound represented by formula (2):
- wherein
- R represents an alkyl group, an alkoxy group, an aryl group, an ester group, an aralkyl group, an alkenyl group, or an alkynyl group, and
- Nphth represents an N-phthaloyl group:
- the method comprising mixing a compound represented by formula (3):
- wherein R and Nphth are as defined in formula (1) above
- with a fluorinating agent in an organic solvent in presence of a catalyst to fluorinate an α-position of the compound represented by formula (3).
3 more elements
Dependencies are inferred from the claim text.