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US 2025/0345488 A1Published application
Crosslinked hydrogels with enhanced radiopacity for medical applications
AssigneeBoston Scientific Scimed, Inc.
InventorYen-Hao Hsu
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AssigneeBoston Scientific Scimed, Inc.
InventorYen-Hao Hsu
Estimating the term…
In some aspects, the present disclosure provides a radiopaque, reactive polymer comprising one or more hydrophilic polymer regions, the one or more hydrophilic polymer regions having first and second ends and comprising at least one hydrophilic polymer segment, a plurality of iodinated amino-acid residues, wherein at least one of the plurality of iodinated amino-acid residues is linked to each of the hydrophilic polymer regions, and a plurality of reactive moieties, wherein at least one of the plurality of reactive moieties is linked to each of the plurality of iodinated amino-acid residues and wherein the reactive moieties each comprise an electrophilic group. In other aspects the present disclosure pertains to systems that comprise such a radiopaque, reactive polymer and a compound having a plurality of nucleophilic moieties that reacts with the radiopaque, reactive polymer to form a crosslinked reaction product, as well as methods of treatment using the same.
A radiopaque, reactive polymer comprising (a) one or more hydrophilic polymer regions, the one or more hydrophilic polymer regions having first and second ends and comprising at least one hydrophilic polymer segment, (b) a plurality of iodinated amino-acid residues, wherein at least one of the plurality of iodinated amino-acid residues is linked to each of the hydrophilic polymer regions, and (c) a plurality of reactive moieties, wherein at least one of the plurality of reactive moieties is linked to each of the plurality of iodinated amino-acid residues and wherein the reactive moieties each comprise an electrophilic group.
A system for forming a hydrogel composition that comprises (1) a compound having a plurality of nucleophilic moieties;
A method of treatment comprising administering to a subject a mixture that comprises (1) a radiopaque, reactive polymer comprising (a) one or more hydrophilic polymer regions, the one or more hydrophilic polymer regions having first and second ends and comprising at least one hydrophilic polymer segment, (b) a plurality of iodinated amino-acid residues, wherein at least one of the plurality of iodinated amino-acid residues is linked to each of the hydrophilic polymer regions, and (c) a plurality of reactive moieties, wherein at least one of the plurality of reactive moieties is linked to each of the plurality of iodinated amino-acid residues and wherein the reactive moieties each comprise an electrophilic group;
Dependencies are inferred from the claim text.