Tetrahydro-1h-cyclopenta[cd]indene derivatives as hypoxia inducible factor-2(alpha) inhibitors

A compound of Formula (IA):

• wherein:
• X1 is CH or N;
• R1 is hydroxy, halo, amino, —OP(O)(OH)2, —OCH2OP(O)(OH)2, —OCOR10, —OCOOR11, —OCONR12R13, —OCHR14OCOR15 or —OCHR14OCOOR15a where R10, R11, and R15 and R15a are independently alkyl or alkyl substituted with amino, carboxy or hydroxy, R12 and R13 are independently hydrogen, alkyl, or alkyl substituted with amino, carboxy or hydroxy or R12 and R13 together with the nitrogen atom to which they are attached form optionally substituted heterocyclyl, and each R14 is hydrogen, alkyl, or haloalkyl;
• R2 is hydrogen, deuterium, alkyl, halo, haloalkyl, alkenyl, or alkynyl;
• R2a is hydrogen, halo, or deuterium;
• R3 and R4 are independently hydrogen, deuterium, alkyl, cycloalkyl, halo, haloalkyl, hydroxyalkyl, or alkoxyalkyl;
• or
• R3 and R4 together with the carbon to which they are attached form oxo, 3 to 6 membered cycloalkylene, or 4 to 6 membered optionally substituted heterocyclylene;
• R5 is hydrogen, deuterium, alkyl, halo, haloalkyl, hydroxy, or alkoxy;
• R6 is hydrogen, deuterium, alkyl, cycloalkyl, or halo;
• or
• R5 and R6 together with the carbon to which they are attached form oxo, alkyldienyl, 3 to 6 membered cycloalkylene, or 4 to 6 membered optionally substituted heterocyclylene;
• provided R5 and R6 and R3 and R4 together with the carbon to which they are attached do not form oxo, cycloalkylene or optionally substituted 4 to 6 membered heterocyclylene simultaneously;
• R7 is hydrogen, deuterium, alkyl, alkoxy, cyano, halo, haloalkyl, or haloalkoxy;
• L is a bond, S, SO, SO2, O, CO, or NR16 where R16 is hydrogen or alkyl;
• R8 is alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, cycloalkyl, cycloalkenyl, bicyclic cycloalkyl, oxocycloalkenyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, spirocycloalkyl, spiroheterocyclyl, heterocyclylalkyl, heteroaryl, or heteroaralkyl wherein aryl or heteroaryl, each by itself or as part of aralkyl or heteroaralkyl, or heterocyclyl by itself or as part of heterocyclylalkyl is substituted with Ra, Rb, Rc, Rg and Rh wherein Ra, Rb, and Rc are independently selected from hydrogen, deuterium, alkyl, haloalkyl, haloalkyloxy, alkoxy, hydroxy, halo, cyano, hydroxyalkyl, alkoxyalkyl, aminoalkyl, alkenyl, alkynyl, alkylidenyl, optionally substituted aryl, optionally substituted heteroaryl, and optionally substituted heterocyclyl and Rg and Rh are independently selected from hydrogen, deuterium, and halo;
• and
• R9 is hydrogen, alkyl, cycloalkyl, hydroxy, alkoxy, cyano, halo, haloalkyl, haloalkoxy, alkylsulfoxide, alkylsulfonyl, or heteroaryl wherein the heteroaryl is optionally substituted with Rd, Re, and Rf independently selected from hydrogen, alkyl, haloalkyl, haloalkoxy, alkoxy, hydroxy, halo, and cyano;
• or
• when R9 and R2 are attached to the same carbon atom, they can combine to form oxo, alkyldienyl, 3 to 6 membered cycloalkylene, or 4 to 6-membered heterocyclylene;
• R9a is hydrogen, halo, or deuterium;
• a pharmaceutically acceptable salt thereof.