A formulation for treatment of pigmentary disorders
OwnerRamakrishna Reddy ISANAKAinventor
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Abstract
The present invention relates to a peptide for treatment of pigmentary disorders. The invention also relates to stable topical formulation for treatment of pigmentary disorders. The present invention further relates to method of preparation of such formulation and uses thereof for treatment or prevention of pigmentary disorders.
Claims19
A pharmaceutical formulation comprising 0.01 to 1% w/v of a peptide of SEQ. ID NO 1 or variant thereof and one or more suitable pharmaceutically acceptable excipients for treating, preventing and/or ameliorating one or more symptoms of pigmentary disorders.
A method of preparing pharmaceutical formulation for treating, preventing and/or ameliorating one or more symptoms of pigmentary disorders comprising the steps:
- a) adding required quantity of water and decapeptide of SEQ. ID NO 1 or variant thereof in a container and stirring at suitable speed by suitable means until clear solution is obtained;
- b) adding required quantity of sucrose in a separate container and stirring at suitable speed by suitable means until completely dissolved;
- c) adding sucrose solution obtained in step ‘b’ to the clear solution obtained in step ‘a’;
- d) adding required quantity of pharmaceutically acceptable excipients to the clear solution obtained in step ‘a’ under continuous stirring until a clear homogenous solution of the pharmaceutical formulation is obtained.
A method of treating, preventing and ameliorating one or more symptoms of pigmentary disorders in a subject in need thereof, said method comprising administering a therapeutically effective amount of a formulation comprising a therapeutically effective amount of peptide of SEQ. ID NO 1 or variant thereof wherein the formulation enhances melanin synthesis and/or suppresses autoimmune targeting of melanocytes and/or inhibits tyrosinase activity and/or reduces levels of cytokines.
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Dependencies are inferred from the claim text.