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US 2025/0326784 A1Published application
Oxysterols and methods of use thereof
AssigneeSage Therapeutics, Inc.
InventorsGabriel Martinez Botella, Boyd L. Harrison, Albert Jean Robichaud, Francesco G. Salituro
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Abstract
Compounds are provided according to Formula (III): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R5, and n are as defined herein, and at least one hydrogen is replaced with a deuterium. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
Claims25
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is hydrogen or deuterium;
- each of R2 and R3 is independently deuterium or —C1-6 alkyl;
- R4 is hydrogen or deuterium;
- R5 is absent, hydrogen, or deuterium;
- n is 1 or 2;
- represents a single or double bond, wherein when one is a double bond, the other is a single bond and R5 is absent;
- and
- at least one of R1, R2, R3, R4, or R5 is deuterium.
6 more elements
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(canceled)
(canceled)
-22. (canceled)
(canceled)
A compound selected from the group consisting of:
Dependencies are inferred from the claim text.