Single insertion delivery system for treating embolism and associated systems and methods

A clot treatment system, comprising:

• an aspiration catheter defining a lumen and having a distal portion and a proximal portion;
• a hub coupled to the proximal portion of the aspiration catheter and configured to provide access to the lumen of the aspiration catheter;
• a side port coupled to the hub and fluidly coupled to the lumen of the aspiration catheter;
• an aspiration source configured to be coupled to the side port and configured to aspirate the lumen of the aspiration catheter;
• a valve insert configured to be releasably coupled to the hub, wherein the valve insert defines an insertion lumen, and wherein the valve insert is actuatable between a first position in which the insertion lumen is sealed and a second position in which the insertion lumen is unsealed;
• and
• a clot treatment device configured to be inserted through the hub and the lumen of the aspiration catheter.

A system for treating clot material in a vasculature of a patient, comprising:

• a catheter defining a lumen and having a distal portion and a proximal portion, wherein the catheter is shaped and sized to be positioned within the vasculature such that the distal portion is proximate to the clot material;
• a hub having a proximal portion and a distal portion, wherein the distal portion of the hub is coupled to the catheter;
• a side port coupled to the hub between the proximal portion of the hub and the distal portion of the hub, wherein the side port is fluidly coupled to the lumen of the aspiration catheter;
• an aspiration source configured to be coupled to the side port and configured to aspirate the lumen of the aspiration catheter;
• and
• a hemostasis valve configured to be releasably coupled to the proximal portion of the hub, wherein the hemostasis valve is actuatable between (a) a sealed position in which fluid is inhibited from passing through the hemostasis valve from the lumen of the aspiration catheter and (b) an unsealed position in which fluid can at least partially pass through the hemostasis valve from the lumen of the aspiration catheter.