Brown fat-selective adipokines
AssigneeUniversity of Massachusetts
InventorsYong-Xu Wang, Qingbo Chen
Life of this patent
Estimating the term…
Abstract
Methods of treating or reducing the risk of obesity and/or obesite-related disorders, e.g., metabolic syndrome, hepatic and non-hepatic steatosis, and diabetes, using C20orf27 proteins or nucleic acids.
Claims21
A method of treating, or reducing risk of, obesity or a disorder associated with obesity, or improving glycemic control, in a mammalian subject, the method comprising administering a therapeutically effective amount of Chromosome 20 Open Reading Frame 27 (C20orf27) to a subject in need thereof.
A viral vector comprising a nucleic acid encoding a polypeptide comprising a sequence that is at least 80% identical to SEQ ID NO:2, or an active fragment thereof.
An isolated polypeptide that is at least 80% identical to SEQ ID NO:2, or an active fragment thereof, and comprises one or more modifications.
A pharmaceutical composition comprising a C20orf27 polypeptide, or a nucleic acid encoding a C20orf27 polypeptide, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.