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US 2025/0320233 A1Published application
Arginase inhibitor and pharmaceutical composition comprising the same
AssigneeDaewoong Pharmaceutical Co., Ltd.
InventorsWol Young Kim, Seung Jae Jeong, Ji Duck Kim, Eungi Kim, Iljin Shin, Joon Seok Park
Life of this patent
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Abstract
The present disclosure relates to a compound represented by Chemical Formula 1 in the present specification, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same can be used favorably for preventing or treating cancer or tumors.
Claims13
A compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt thereof:
- in Chemical Formula 1,
- R1 and R2 are each independently hydrogen;
- a C1-4 alkyl which is unsubstituted or substituted with amino, (C1-4 alkyl)amino, or di(C1-4 alkyl)amino;
- or -L1-R′1,
- L1 is —CO—, —CO—O—, —(CO)—O—(C1-4 alkylene)-O—(CO)—, or —CH2—O—CO—,
- R′1 is —CH(NH2)—RA, —CH(N(CH3)2)—RA, RB, or RC,
- R3 is hydroxy, or -L3-R′3,
- L3 is —NH—, —O—, or —O—(CH2)n3—O—CO—,
- R′3 is —CH(COOH)—RA, —CH(NH2)—RA, RB, or RC,
- each RA is independently hydrogen;
- or a C1-6 alkyl which is unsubstituted or substituted with hydroxy, mercapto, hydroseleno, guanidino, amino, carboxy, carbamoyl, C1-6 alkylthio, phenyl, hydroxyphenyl, or C4-10 heteroaryl containing one or two N,
- each RB is independently a C4-10 heterocycloalkyl containing N,
- each Rc is independently a C1-6 alkyl group which is unsubstituted or substituted with a C6-10 aryl or a C4-10 heterocycloalkyl containing N;
- a C6-10 aryl which is unsubstituted or substituted with a C1-6 alkoxy;
- or a C3-6 cycloalkyl, and
- n3 is an integer of 1 to 3.
13 more elements
A compound, which is any one selected from the group consisting of the following:
- wherein,
- PG1 and PG2 are each independently identical or different, and represent a protecting group.
Dependencies are inferred from the claim text.