Substituted 4-phenylpiperidines, their preparation and use

A method of lowering a retinal concentration of a bisretinoid in a subject, comprising administering to the subject a compound of Formula:

• wherein
• R1, R2, R3, R4, and R5 are each independently H, halogen, CF3, or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H;
• R6 is H, OH, or halogen;
• and
• B has the structure:
• wherein
• α, β, χ, and δ are each independently absent or present, and when present each is a bond;
• X is C or N;
• Z1 is N;
• Z2 is N or NR7,
• wherein R7 is H, C1-C4 alkyl, or oxetane;
• and
• Q is a substituted or unsubstituted 5, 6, or 7 membered ring structure,
• wherein
• when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or
• R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or
• R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or
• R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or
• R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or
• R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than
• or a pharmaceutically acceptable salt thereof.