Stat6 degraders

A compound of formula (I)

• wherein:
• A′ is selected from
• and
• X1 is selected from N and CR11;
• X2 is selected from N and CR12;
• and X3 is selected from N and CR13, provided that only one of X1, X2 and X3 may be N;
• X4 is selected from CR4R4 and CO;
• X5 is selected from N and oxidized N;
• Y1 is selected from N and CR7;
• Y2 is selected from N and CR8;
• Y3 is selected from N and CR17;
• Z is selected from N and CR10;
• R is NHR0;
• R0 is selected from hydrogen, C1-4alkyl, C3-4 cycloalkyl, C3-4 cycloalkyl-C1-4alkyl, phenyl-C1-4 alkyl, halo-C1-4alkyl, —(CH2)n—O—C1-4alkyl, —(CH2)n—CO—R′, and —(CH2)n—CO2R′, wherein said phenyl is optionally substituted one or more times with a substituents independently selected from halogen, C1-4alkyl, halo-C1-4alkyl, C3-4cycloalkyl, hydroxy, C1-4alkoxy, cyano, —NR′R″, —CONR′R″, and —CO2R′, and wherein R′ and R″ are each independently selected from hydrogen and C1-4alkyl, and n is 0, 1 or 2;
• R1 and R″ are independently selected from hydrogen, fluoro, and C1-4alkyl;
• R2 is selected from hydrogen, C1-5alkyl, —SO2—C1-4alkyl and deuterated C1-4alkyl, wherein said C1-5alkyl may optionally be substituted one or more times with halogen;
• R3 is selected from hydrogen, C1-4alkyl, and deuterated C1-4alkyl;
• each of R4 and R6 is independently selected from hydrogen, C1-4alkyl, and C1-4 alkoxy, said C1-4alkyl and C1-4alkoxy may optionally be substituted with one or more halogen;
• R5 is selected from hydrogen, halogen, C1-4alkyl and C1-4alkoxy, wherein said C1-4alkyl and C1-4alkoxy may optionally be substituted with one or more halogen;
• R10 is selected from hydrogen and fluoro;
• or
• R5 and R10 together form a bond between the two carbons to which they are attached;
• R5a is hydrogen;
• or R5 and R5a are both fluoro or R5 and R5a together with the atom attached thereto form a CO group;
• R5b and R5c are each independently selected from hydrogen and fluoro;
• R7, R8, and R17 are each independently selected from hydrogen, halogen, cyano, C1-4alkyl and C1-4alkoxy, and C3-4cycloalkyl, wherein said C1-4alkyl and C1-4alkoxy may optionally be substituted with one or more halogen;
• R9 is -A-L-LBM;
• R11, R12, and R13 are each independently selected from hydrogen, halogen, C1-4alkyl, C3-4 cycloalkyl, C1-4alkoxy, hydroxy, cyano, —NR′R″, —CONR′R″, —CO2R′, and —CO—(CH2)mOH, wherein said C1-4alkyl is optionally substituted one or more times with a substituent independently selected from halogen, hydroxy and C1-4alkoxy, and wherein m is 1, 2 or 3 and wherein R′ and R″ are each independently selected from hydrogen and C1-4alkyl;
• or
• R11 and R0 together with the atoms attached thereto form a 5-6 membered heteroaromatic or heterocyclic ring containing one or two N atoms, wherein said 5-6 membered heteroaromatic ring or heterocyclic ring containing one or two N atoms is optionally substituted one or more times with a substituent independently selected from halogen, C1-4alkyl, halo-C1-4alkyl, C3-4 cycloalkyl, hydroxy, C1-4alkoxy, cyano, —C(O)CF3, —NR′R″, —CONR′R″, and —CO2R′, wherein said C1-4alkyl may optionally be substituted one or more times with a substituent independently selected from halogen and C1-4alkoxy, and wherein R′ and R″ are each independently selected from hydrogen and C1-4alkyl;
• R12 and R13 are each independently selected from hydrogen, halogen, C1-4alkyl, C3_4 cycloalkyl, C1-4alkoxy, hydroxy, cyano, —NR′R″, —CONR′R″, —CO2R′, —CO—CO2R′ and —CO—(CH2)mOH, wherein said C1-4alkyl is optionally substituted one or more times with a substituent independently selected from halogen, hydroxy and C1-4alkoxy;
• A is CO;
• L is:
• wherein
• R17 is selected from hydrogen, chloro, and fluoro;
• R18 is selected from hydrogen, fluoro, and hydroxy;
• R19 is selected from hydrogen and C1-4alkyl, wherein said C1-4alkyl may optionally be substituted one or more times with fluoro;
• R20 is independently selected from hydrogen and fluoro;
• n1 is selected from 0 and 1;
• X7 is selected from N and CH;
• and
• LBM is selected from:
• wherein
• X8 is selected from O, C(O)NH, and NH;
• R21 is selected from hydrogen, fluoro, chloro, cyano, C1-4alkyl and trifluoromethyl;
• R22 is selected form hydrogen and fluoro;
• R23 is selected from hydrogen, halogen, C1-4alkyl, and C1-4alkoxy;
• and
• or a pharmaceutically acceptable salt or stereoisomer thereof.