Systems and methods for manufacturing a silk fibroin solution and powders containing silk fibroin

A silk manufacturing system comprising:

• a first processing substation comprising at least one reactor vessel configured to receive silk inputs, extract silk fibroin proteins therefrom, and produce a silk fibroin-based solution, such that the silk fibroin-based solution is substantially free of sericin, wherein the first processing substation is configured to extract the silk fibroin proteins via degumming, rinsing, and dissolving processes within a single one of the at least one reactor vessel;
• and
• a second processing substation in fluid communication with the first processing substation, the second processing substation configured to receive and purify the silk fibroin-based solution from the first processing substation, wherein the second processing substation comprises a filtration module comprising at least one membrane configured to substantially remove the second compound and produce a purified silk fibroin-based solution.