Back to results
US 2025/0288703 A1Published application
Alpha Emitter Compositions And Methods
AssigneeNant Holdings IP, LLC
InventorPatrick Soon-Shiong
Life of this patent
Estimating the term…
Abstract
Compositions, methods, and uses of an alpha emitter are provided in which the alpha emitter is coupled to carrier protein via a cleavable coupling moiety. The coupling moiety is preferably cleavable in an acidic tumor microenvironment, and as such will enrich the alpha emitter upon cleavage within the tumor microenvironment.
Claims20
A synthetic alpha-emitter-conjugated compound, comprising:
- an alpha-emitter coupled to a coupling moiety that comprises a linker portion and a chelator portion;
- wherein the linker portion has a protein binding group that is a thiol reactive group, a hydroxyl reactive group, or an amino reactive group and wherein the chelator portion chelates the alpha-emitter;
- and
- wherein the coupling moiety comprises an acid-labile hydrazone group that is preferentially cleavable in a tumor microenvironment.
1 more element
Dependencies are inferred from the claim text.