Phospho-tau antibodies and methods of use

A nucleic acid encoding an antibody or antigen-binding fragment that binds to a phosphorylated tau polypeptide, comprising:

• a. a nucleic acid sequence encoding a heavy chain of the antibody or antigen-binding fragment, wherein the heavy chain comprises a variable heavy chain (VH) domain comprising HCDR1 sequence comprising SEQ ID NO:
• 2, HCDR2 sequence comprising SEQ ID NO:
• 7, and HCDR3 sequence comprising SEQ ID NO:
• 11;
• or
• b. a nucleic acid sequence encoding a light chain of the antibody or antigen-binding fragment, wherein the light chain comprises a variable light chain (VL) domain comprising LCDR1 sequence comprising SEQ ID NO:
• 15, LCDR2 sequence comprising SEQ ID NO:
• 21, and LCDR3 sequence comprising SEQ ID NO:
• 25.