Microfluidic devices for evaluating fibrosis in material implantation and cancer

A fibrotic diagnostic system comprising:

• a microfluidic device comprising:
• a device housing defining a device interior;
• a plurality of channels within the device interior, the plurality of channels comprising:
• a first channel configured to receive a target object, a matrix, and a first biological composition that is configured to promote fibrosis of the target object,
• a second channel configured to receive a second biological composition that is configured to promote fibrosis of the target object,
• a first septum separating the first and second channels and comprising a first plurality of openings providing fluid communication between the first and second channels,
• a third channel configured to receive a third biological composition configured to promote fibrosis of the target object, and
• a second septum separating the first and third channels and comprising a second plurality of openings providing fluid communication between the first and third channels;
• and
• a plurality of a channel ports disposed within the device housing that is in fluid communication with the plurality of channels, the plurality of channel ports comprising:
• a first set of channel ports in fluid communication with the first channel,
• a second set of channel ports in fluid communication with the second channel, and
• a third set of channel ports in fluid communication the third channel,
• wherein each set of channel ports comprises one or more channel ports.