Nitrogen-containing derivatives of narasin, synthesis and uses thereof
AssigneesCentre National De La Recherche Scientifique, Institut National De La Sante Et De La Recherche Medicale (Inserm), Institut Curie
InventorsRaphaël RODRIGUEZ, Tatiana CAÑEQUE, Sebastian MÜLLER, Michal ANTOSZCZAK
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Abstract
The present invention relates to nitrogen-containing derivatives of narasin having the formula (I), as well as synthesis and uses thereof, in particular for the treatment and/or prevention of cancer. Also disclosed are medicaments including the nitrogen-containing derivatives of narasin, which include medicaments for preventing cancer metastasis and/or for preventing cancer recurrence and/or for decreasing resistance to a chemotherapy in a subject.
Claims19
A compound having the formula (I):
- wherein R is a group —NR1R2, R1 and R2 being identical or different, preferably different, and independently chosen from the group consisting of:
- H, a (C1-C20)alkyl group, a (C3-C6)cycloalkyl group, a (C2-C20)alkynyl group, and a (C6-C10)aryl(C1-C6)alkyl group, as well as its epimers.
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Dependencies are inferred from the claim text.