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US 2025/0243247 A1Published application
Chimeric antigen receptor (car) modulation
AssigneeTrustees of Boston University
InventorsJohn NGO, Wilson WONG, Meng Lai Nicole WONG, Huishan LI, Elliot P. TAGUE
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Abstract
The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.
Claims21
1-30. (canceled)
A polypeptide comprising:
- (a) an extracellular binding domain;
- (b) a transmembrane domain;
- and
- (c) a peptide domain which is specifically bound by a repressible protease.
1 more element
Dependencies are inferred from the claim text.