Polyols and polyol-based hydrogels with anti-cancer activity
AssigneeThe Florida International University Board of Trustees
InventorsArti VASHIST, Andrea D. RAYMOND, Prem CHAPAGAIN, Madhavan P. NAIR, Carolyn D. RUNOWICZ
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Abstract
The present invention provides compositions and methods for selectively treating a cancer or tumor utilizing an effective amount of a vegetable oil-derived polyol or hydrogel particles comprising a vegetable oil-derived polyol. In some embodiments, the cancer is a gynecologic cancer, specifically an ovarian cancer. In other aspects, the present invention provides a method of targeting and imaging various tumors and/or tumor associated macrophages (TAMs).
Claims8
A method of selectively imaging a tumor and/or tumor associated macrophages (TAMs), comprising
- introducing into the environment of said TAMs, an effective amount of hydrogel nanoparticles and/or microparticles comprising a gel of one or more biopolymer(s) and one or more vegetable oil-derived polyol(s);
- and
- visualizing said tumor and/or TAMs at wavelengths 450 to 750 nm and 710 to 810 nm.
Dependencies are inferred from the claim text.